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Submitted
Nov 20, 2019
Accepted
Jun 21, 2020
Published
Dec 1, 2019
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Abstract

Cucurbitane derivative has been isolated from methanol extract of the leaves of bitter melon (Momordica charantia). Purification of methanol extract using vacuum column chromatography method using n-hexane: ethyl acetate as the mobile phase was obtained a white powder isolate. This isolate was elucidated to obtain chemical structures based on spectroscopic data (FT-NMR, FT-IR, and LC-MS/MS) and resulted a cucurbitane derivate, namely momordicine I. The MeOH extract and the isolate were evaluated for α-glucosidase inhibitory effect. Both MeOH extract and momordicine I showed moderate activities with %inhibition 27.34% and 15.79 % at 100 µg/mL repectively.

Keywords

Cucubitane Momordica charantia momordicine I α-glucosidase

Article Details

Author Biography

Andi Fikrah Auliya Pamenta, Universitas Hasanuddin

Magister student of Chemistry Departement, Mathematics and Science Faculty of Universitas Hasanuddin
How to Cite
Pamenta, A. F. A. (2019). α-Glucosidase Inhibitory Activity Of Cucurbitane Derivate Isolated From Methanol Extract Of Momordica charantia L. Leaves. Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta), 12(2), 99-103. https://doi.org/10.20956/ica.v12i2.8341
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