Factors Contributing to Bleeding in Breast Cancer Wounds: A Literature Review

https://doi.org/10.20956/icon.v9i1.34991

Authors

  • Nurmila Sari Master of Nursing, Institut Teknologi dan Kesehatan Muhammadiyah Kalimantan Barat, Pontianak-Indonesia
  • Haryanto Haryanto ound Management and Medical Surgical Nursing Department, Institut Teknologi dan Kesehatan Muhammadiyah Kalimantan Barat, Pontianak-Indonesia
  • Lidia Hastuti Child and Maternity Nursing Department, Institut Teknologi dan Kesehatan Muhammadiyah Kalimantan Barat, Pontianak-Indonesia

Keywords:

risk factors, bleeding, breast cancer

Abstract

Aims: In Indonesia, breast cancer ranks first in the number of new cases; there is a significant increase in the number of cases every year. Complications of breast cancer include bleeding that affects quality of life, psychology, activity limitations, anemia, increased treatment time, economic burden, and the threat of death. Breast cancer is often found in advanced stages, increasing the risk of bleeding. The literature review analyzes research articles that discuss factors associated with breast cancer wound bleeding. Methods: Inclusion criteria include articles discussing breast cancer bleeding, cancer in general, cancer wounds, themes relevant to research, research can be a quantitative, qualitative, mixed method, meta-analysis, in English and Indonesian, from 2013 to 2023, full text. Keywords in the database are "risk factors," bleeding, breast cancer, and malignant wound. Literature searches use journal databases, namely Pubmed and ScienceDirect. This research uses the author's literature review method to analyze, evaluate, and criticize published research results. Results: Fifteen articles met the inclusion criteria, most of them retrospective, examining factors of anticoagulation therapy on breast cancer bleeding, articles examining bleeding factors in several types of cancer, and five articles examining factors of post-operative breast cancer bleeding. Conclusion:  Breast cancer wound bleeding factors are chemotherapy, radiation, comorbidities, malignant fungating wounds, BMI≥40, dressings, thrombocytopenia, reconstructive surgery, advanced stage, infection, and therapy (anticoagulants, anti-inflammatory pain relief, NSAIDs). Suggestions for further research are analyzing various bleeding factors, examining which factors are most related to bleeding, and looking at the pattern of relationships between several factors in bleeding.

Downloads

Download data is not yet available.
Dimensions

Agra, G., Pereira dos Santos, J., Tamar Oliveira de Sousa, A., André Gouveia, B. de L., Freires de Brito, D. T., de Lima Macêdo, E., de Souza Medeiros, M. V., Silva Pimentel, E. R., Simplício de Oliveira, P., Costa Ferreira, T. M., Martins do Nascimento Oliveira, D., dos Santos Oliveira, S. H., Guimarães Oliveira Soares, M. J., & Lopes Costa, M. M. (2016). Malignant Neoplastic Wounds: Clinical Management Performed by Nurses. International Archives of Medicine, 9(344) https://scholar.google.com/scholar?hl=id&as_sdt=0%2C5&q=Malignant+Neoplastic+Wounds%3A++Clinical+Management+Performed+by+Nurses&btnG=

Agustiyaningsih, A. F., Rohyadi, Y., Diah KD, S., & Tursini, Y. (2021). Gambaran Kualitas Hidup Pasien Kanker Payudara. Jurnal Keperawatan Indonesia, 1(1). https://doi.org/10.34011/jkifn.v1i1.86

Angelini, D. E., Radivoyevitch, T., McCrae, K. R., & Khorana, A. A. (2019). Bleeding Incidence and Risk Factors Among Cancer Patients Treated with Anticoagulation. American Journal of Hematology, 94(7), 780–785. https://doi.org/10.1002/ajh.25494

Beers, E. H. (2019). Palliative Wound Care: Less Is More. Surgical Clinics of North America, 99(5), 899–919. https://doi.org/10.1016/j.suc.2019.06.008

Gerber, B., Von Minckwitz, G., Eidtmann, H., Rezai, M., Fasching, P., Tesch, H., Eggemann, H., Schrader, I., Kittel, K., Hanusch, C., Solbach, C., Jackisch, C., Kunz, G., Blohmer, J. U., Huober, J., Hauschild, M., Nekljudova, V., Loibl, S., & Untch, M. (2014). Surgical Outcome After Neoadjuvant Chemotherapy and Bevacizumab: Results from The Geparquinto Study (GBG 44). Annals of Surgical Oncology, 21(8), 2517–2524. https://doi.org/10.1245/s10434-014-3606-9

International Agency for Research on Cancer (WHO). (2020). Global Cancer Observatori-Cancer Today. https://gco.iarc.fr/today/home

Johnstone, C., & Rich, S. E. (2018). Bleeding In Cancer Patients and Its Treatment: A Review. In Annals of Palliative Medicine, 7(2), 265–273. https://doi.org/10.21037/apm.2017.11.01

Kementerian Kesehatan Republik Indonesia. (2022). Kanker Payudara Paling Banyak di Indonesia, Kemenkes Targetkan Pemerataan Layanan Kesehatan. https://www.kemkes.go.id/article/view/22020400002/kanker-payudara-paling-banyak-di-indonesia-kemenkes-targetkan-pemerataan-layanan-kesehatan.html

Komite Nasional Penaggulangan Kanker (KNPK). (2015) Panduan Nasional Penanganan Kanker (Kanker Payudarah). Kementerian Kesehatan Republik Indonesia

Loeffler, A. G. & Hart, M. N. (2017). Patofisiologi Untuk Profesi Kesehatan: Epidemiologi, Diagnosis, Dan Pengobatan. Edisi ke 6. Penerbit Buku Kedokteran EGC.

Nadiva, D. H & Muafiro, A., (2019). Deskripsi Perkembangan Keadaan Luka Kanker Payudara Post Mastektomi Setelah Perawatan Luka. Jurnal Keperawatan, XIII(1), 49-56. https://www.academia.edu/108036665/Deskripsi_Perkembangan_Keadaan_Luka_Kanker_Payudara_Post_Mastektomi_Setelah_Perawatan_Luka

Nicodème, M., Dureau, S., Chéron, M., Kriegel, I., Trenchand, M., Bauër, P., & Fromantin, I. (2021). Frequency and Management of Hemorrhagic Malignant Wounds: A Retrospective, Single-Center, Observational Study. Journal of Pain and Symptom Management, 62(1), 134–140. https://doi.org/10.1016/j.jpainsymman.2020.11.031

Nishimoto, Y., Yamashita, Y., Kim, K., Morimoto, T., Saga, S., Amano, H., Takase, T., Hiramori, S., Oi, M., Akao, M., Kobayashi, Y., Toyofuku, M., Izumi, T., Tada, T., Chen, P., Murata, K., Tsuyuki, Y., Sasa, T., Sakamoto, J.,…Kinoshita, M. (2020). Risk Factors for Major Bleeding During Anticoagulation Therapy in Cancer-Associated Venous Thromboembolism - From the COMMAND VTE registry. Circulation Journal, 84(11), 2006–2014. https://doi.org/10.1253/circj.CJ-20-0223

Nwaogu, I. Y., Bommarito, K., Olsen, M., A. Margenthaler, J. A. (2015). Economic impact of bleeding complications after mastectomy. Journal of Surgical Research, 1, 77-83. http://dx.doi.org/10.1016/j.jss.2015.03.084

Okada, N., Narita, Y., Takada, M., Kato, H., Ambo, Y., Nakamura, F.,…Kashimura, N. (2015). Early removal of drains and the incidence of seroma after breast surgery. Breast Cancer, 22(1), 79–83. https://doi.org/10.1007/s12282-013-0457-3

Orr, J. P., Shammas, R. L., Thomas, A. B., Truong, T., Cho, E. H., Kuchibhatla, M., & Hollenbeck, S. T. (2019). Bleeding after Free Flap-Based Breast Reconstruction: A NSQIP Analysis. Journal of Reconstructive Microsurgery, 35(6), 417–424. https://doi.org/10.1055/s-0038-1677037

Patell, R., Gutierrez, A., Rybicki, L., & Khorana, A. A. (2017). Identifying predictors for bleeding in hospitalized cancer patients: A cohort study. Thrombosis Research, 158, 28-43. https://www.sciencedirect.com/science/article/pii/S0049384817304498bleeding. The British Journal of Surgery, 104(12), 1665–1674. https://doi.org/10.1002/bjs.10592

Risnah (2020). Konsep Medis Dan Keperawatan Pada Gangguan Sistem Onkologi. Jariah Publishing Intermedia.

Valachis, A., Garmo, H., Fredriksson, I., Sund, M., Lagerqvist, B., & Holmberg, L. (2020). Bleeding Risk In Breast Cancer Patients During Concomitant Administration Of Warfarin And Tamoxifen: A Population-Based Nested Case-Control Study. Breast Journal, 26(5), 981–987. https://doi.org/10.1111/tbj.13759

Weddle, K. J., Kiel, P. J., & Patel, P. J. (2019). Assessment Of Bleeding Incidences Associated with Rivaroxaban Therapy in Adults with Solid Tumors. In Journal of Oncology Pharmacy Practice, 25(1), 192–197. https://doi.org/10.1177/1078155218765635

Zakai, N. A., Walker, R. F., MacLehose, R. F., Adam, T. J., Alonso, A., & Lutsey, P. L. (2018). Impact Of Anticoagulant Choice on Hospitalized Bleeding Risk When Treating Cancer-Associated Venous Thromboembolism. Journal of Thrombosis and Haemostasis, 16(12), 2403–2412. https://doi.org/10.1111/jth.14303

Published

2024-08-27

How to Cite

Sari, N. ., Haryanto, H., & Hastuti, L. (2024). Factors Contributing to Bleeding in Breast Cancer Wounds: A Literature Review. Indonesian Contemporary Nursing Journal (ICON Journal), 9(1), 51-61. https://doi.org/10.20956/icon.v9i1.34991